Kortenkamp, A., Faust, M., Scholze, M. and Backhaus, T. (2007) Low-level exposure to multiple chemicals: reason for human health concerns? Environmental Health Perspectives, 115 (Suppl 1). pp. 106-114. 10.1289/ehp.9358..
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The widely held view that mixtures of dissimilarly acting chemicals are "safe" at levels below NOAELs is not supported by empirical evidence. We show that this view is also based on the erroneous assumption that NOAELs can be equated with zero-effect levels. Thus, on the basis of published evidence, it is difficult to rule out the possibility of mixture effects from low-dose multiple exposures.
|Uncontrolled Keywords:||dose addition, independent action, low dose, mixture toxicity, multiple exposures, risk assessment|
|Departments, units and centres:||Department of Pharmacology > Centre for Toxicology|
|Journal or Publication Title:||Environmental Health Perspectives|
|Deposited By:||Library Staff|
|Deposited On:||23 Jun 2011 12:29|
|Last Modified:||23 Jun 2011 12:29|
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