Low-level exposure to multiple chemicals: reason for human health concerns?

Kortenkamp, A., Faust, M., Scholze, M. and Backhaus, T. (2007) Low-level exposure to multiple chemicals: reason for human health concerns? Environmental Health Perspectives, 115 (Suppl 1). pp. 106-114. 10.1289/ehp.9358..

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DOI: 10.1289/ehp.9358.

Abstract

The widely held view that mixtures of dissimilarly acting chemicals are "safe" at levels below NOAELs is not supported by empirical evidence. We show that this view is also based on the erroneous assumption that NOAELs can be equated with zero-effect levels. Thus, on the basis of published evidence, it is difficult to rule out the possibility of mixture effects from low-dose multiple exposures.

Item Type:Article
Uncontrolled Keywords:dose addition, independent action, low dose, mixture toxicity, multiple exposures, risk assessment
Departments, units and centres:Department of Pharmacology > Centre for Toxicology
ID Code:2249
Journal or Publication Title:Environmental Health Perspectives
Deposited By:Library Staff
Deposited On:23 Jun 2011 12:29
Last Modified:23 Jun 2011 12:29

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