Oral plasmid DNA delivery systems for genetic immunisation

Somavarapu, S., Bramwell, V.W. and Alpar, H.O. (2003) Oral plasmid DNA delivery systems for genetic immunisation. Journal of Drug Targeting, 11 (8-10). pp. 547-553. 10.1080/10611860410001683022.

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DOI: 10.1080/10611860410001683022


The use and optimisation of plasmid DNA delivery systems for the purposes of eliciting transgene specific immune responses to orally administered DNA encoded antigen represents a significant challenge. Here, we have outlined a multicomponent polymer modified liposomal delivery system that offers potential for oral administration of plasmid DNA. It is shown that the polymer/liposome formulated DNA is able to elicit markedly enhanced transgene specific cytokine production following in vitro restimulation of splenocytes with recombinant antigen. This is discussed with reference to recent publications and the potential of plasmid DNA delivery systems for the purposes of genetic immunisation, as reported in selected literature, is assessed.

Item Type:Article
Additional Information:Full text available in print and electronically at the School of Pharmacy.
Uncontrolled Keywords:Oral, DNA, Vaccine, Polymer, Liposome
Departments, units and centres:Department of Pharmaceutics > Centre for Drug Delivery Research
ID Code:227
Journal or Publication Title:Journal of Drug Targeting
Deposited By:Library Staff
Deposited On:04 Sep 2007
Last Modified:18 Nov 2011 09:56


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