Regulation of mammalian acetyl-CoA carboxylase.

Munday, M. (2002) Regulation of mammalian acetyl-CoA carboxylase. Biochemical Society Transactions, 30 (Pt 6). pp. 1059-1064.

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Abstract

Acetyl-CoA carboxylase (ACC) plays a critical role in the regulation of fatty acid metabolism and its two isoforms, ACCalpha and ACCbeta, appear to have distinct functions in the control of fatty acid synthesis and fatty acid oxidation, respectively. They are regulated by similar short-term mechanisms of allosteric activation by citrate, and reversible phosphorylation and inactivation, and there is clearly interaction between these mechanisms. AMP-activated protein kinase is the important physiological ACC kinase for both isoforms and yet there is a potential physiological role for cAMP-dependent protein kinase in the hormonally mediated inactivation of ACCalpha, and phosphorylation of ACCbeta in its unique N-terminus.

Item Type:Article
Departments, units and centres:Department of Pharmacology > Department of Pharmacology
ID Code:2275
Journal or Publication Title:Biochemical Society Transactions
Deposited By:Library Staff
Deposited On:23 Jun 2011 16:01
Last Modified:23 Jun 2011 16:01

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