The cell adhesion molecule neurofascin stabilizes axo-axonic GABAergic terminals at the axon initial segment.

Kriebel, M., Metzger, J., Trinks, S., Chugh, D., Harvey, R.J., Harvey, K. and Volkmer, H. (2011) The cell adhesion molecule neurofascin stabilizes axo-axonic GABAergic terminals at the axon initial segment. Journal of Biological Chemistry, 286 (27). pp. 24385-24393. 10.1074/jbc.M110.212191 .

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Official URL: http://www.jbc.org/content/early/2011/05/16/jbc.M110.212191

DOI: 10.1074/jbc.M110.212191

Abstract

Cell adhesion molecules regulate synapse formation and maintenance via transsynaptic contact stabilization involving both extracellular interactions and intracellular postsynaptic scaffold assembly. The cell adhesion molecule neurofascin is localized at the axon initial segment of granular cells in rat dentate gyrus, which is mainly targeted by chandelier cells. Lentiviral shRNA-mediated knockdown of neurofascin in adult rat brain indicates that neurofascin regulates the number and size of postsynaptic gephyrin scaffolds, the number of GABA(A) receptor clusters as well as presynaptic glutamate decarboxylase-positive terminals at the axon initial segment. By contrast, overexpression of neurofascin in hippocampal neurons increases gephyrin cluster size presumably via stimulation of fibroblast growth factor receptor 1 signaling pathways.

Item Type:Article
Uncontrolled Keywords:Axon; Brain; GABA receptors; Gene silencing; Synapses; FGFR1;axon initial segment;gephyrin;neurofascin
Departments, units and centres:Department of Pharmacology > Department of Pharmacology
ID Code:2297
Journal or Publication Title:Journal of Biological Chemistry
Deposited By:Library Staff
Deposited On:06 Oct 2011 11:31
Last Modified:06 Oct 2011 11:31

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