Kriebel, M., Metzger, J., Trinks, S., Chugh, D., Harvey, R.J., Harvey, K. and Volkmer, H. (2011) The cell adhesion molecule neurofascin stabilizes axo-axonic GABAergic terminals at the axon initial segment. Journal of Biological Chemistry, 286 (27). pp. 24385-24393. 10.1074/jbc.M110.212191 .
Full text not available from this repository.
Cell adhesion molecules regulate synapse formation and maintenance via transsynaptic contact stabilization involving both extracellular interactions and intracellular postsynaptic scaffold assembly. The cell adhesion molecule neurofascin is localized at the axon initial segment of granular cells in rat dentate gyrus, which is mainly targeted by chandelier cells. Lentiviral shRNA-mediated knockdown of neurofascin in adult rat brain indicates that neurofascin regulates the number and size of postsynaptic gephyrin scaffolds, the number of GABA(A) receptor clusters as well as presynaptic glutamate decarboxylase-positive terminals at the axon initial segment. By contrast, overexpression of neurofascin in hippocampal neurons increases gephyrin cluster size presumably via stimulation of fibroblast growth factor receptor 1 signaling pathways.
|Uncontrolled Keywords:||Axon; Brain; GABA receptors; Gene silencing; Synapses; FGFR1;axon initial segment;gephyrin;neurofascin|
|Departments, units and centres:||Department of Pharmacology > Department of Pharmacology|
|Journal or Publication Title:||Journal of Biological Chemistry|
|Deposited By:||Library Staff|
|Deposited On:||06 Oct 2011 11:31|
|Last Modified:||06 Oct 2011 11:31|
Item downloaded times since 06 Oct 2011 11:31.
Repository Staff Only: Item control page
School of Pharmacy Staff Only: Edit a copy to replace this item