Excitatory and inhibitory connections show selectivity in the neocortex

Watts, J. and Thomson, A.M. (2005) Excitatory and inhibitory connections show selectivity in the neocortex. Journal of Physiology, 562 (1). pp. 89-97. 10.1113/jphysiol.2004.076984.

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Official URL: http://jp.physoc.org/cgi/content/abstract/562/1/89

DOI: 10.1113/jphysiol.2004.076984


The cerebral cortex is pivotal in information processing and higher brain function and its laminar structure of six distinct layers, each in receipt of a different constellation of inputs, makes it important to identify connectivity patterns and distinctions between excitatory and inhibitory pathways. The ‘feedforward’ projections from layer 4–3 and from 3–5 target pyramidal cells and to lesser degrees interneurones. ‘Feedback’ projections from layer 5–3 and from 3–4, on the other hand, mainly target interneurones. Understanding the microcircuitry may give some insight into the computation and information processing performed in this brain region.

Item Type:Article
Departments, units and centres:Department of Pharmacology > Department of Pharmacology
ID Code:23
Journal or Publication Title:Journal of Physiology
Deposited By:Library Staff
Deposited On:21 Nov 2006
Last Modified:11 Nov 2011 15:57

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