Phenylpropanoid NF-κB inhibitors fromBupleurum fruticosum

Bremner, P., Tang, S., Birkmayer, H., Fiebich, B.L., Muñoz, E., Marquez, N., Rivera, D. and Heinrich, M. (2004) Phenylpropanoid NF-κB inhibitors fromBupleurum fruticosum. Planta Medica, 70 (10). pp. 914-918. 10.1055/s-2004-832616.

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DOI: 10.1055/s-2004-832616

Abstract

Two phenylpropanoids from Bupleurum fruticosum (Apiaceae/Umbelliferae) were shown to inhibit the transcriptional activity induced by PMA or TNFα of an NF-κB-controlled reporter gene. Western blot experiments indicated that the phenylpropanoids did not prevent IκBα degradation, suggesting that their molecular target is at a post-IKB degradation level. Both compounds prevented cytokine (IL-1, IL-6, TNF, IL-8) release and prostaglandin E2 synthesis.

Item Type:Article
Uncontrolled Keywords:NF-κB - Bupleurum fruticosum - Apiaceae - phenylpropanoids - anti-inflammatory natural products (AINP) - cytokine
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry
ID Code:2305
Journal or Publication Title:Planta Medica
Deposited By:Library Staff
Deposited On:07 Oct 2011 10:09
Last Modified:07 Oct 2011 10:09

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