Patel, S.M., Fuente, M.de la, Ke, S., Guimarães, A.M.R., Oliyide, A.O., Ji, X., Stapleton, P.D., Osbourn, A., Pan, Y., Bowles, D.J., Davis, B.G., Schatzlein, A.G. and Yang, M. (2011) High throughput discovery of heteroaromatic-modifying enzymes allows enhancement of novobiocin selectivity. Chemical Communications, 47 (38). pp. 10569-10571. 10.1039/C1CC13552J .
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Glycosylated analogues of novobiocin, discovered using a broad library of enzymes, have 100-fold improved activity against breast, brain, pancreatic, lung and ovarian cancers and ablated associated off-target activity leading to an up to 2.7 × 10(4) fold increase in selectivity.
|Departments, units and centres:||Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry|
|Journal or Publication Title:||Chemical Communications|
|Deposited By:||Library Staff|
|Deposited On:||13 Oct 2011 11:25|
|Last Modified:||13 Oct 2011 11:55|
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