Wells, G., Bradshaw, T.D., Diana, P., Seaton, A., Shi, D-F, Westwell, A.D. and Stevens, M.F.G. (2000) Antitumour benzothiazoles. Part 10: The synthesis and antitumour activity of benzothiazole substituted quinol derivatives. Bioorganic & Medicinal Chemistry Letters, 10 (5). pp. 513-515. 10.1016/S0960-894X(00)00027-5 .
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The synthesis of a series of new antitumour agents, the benzothiazole substituted quinol ethers and esters, is reported via the hypervalent iodine mediated oxidation of hydroxylated 2-phenylbenzothiazoles. The products were found to be active in vitro against human colon and breast cancer cell lines with IC50 values in the nanomolar range.
|Departments, units and centres:||Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry|
|Journal or Publication Title:||Bioorganic & Medicinal Chemistry Letters|
|Deposited By:||Library Staff|
|Deposited On:||20 Oct 2011 15:38|
|Last Modified:||11 Nov 2011 16:30|
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