Wells, G., Bradshaw, T.D., Diana, P., Seaton, A., Shi, D-F, Westwell, A.D. and Stevens, M.F.G. (2000) Antitumour benzothiazoles. Part 10: The synthesis and antitumour activity of benzothiazole substituted quinol derivatives. Bioorganic & Medicinal Chemistry Letters, 10 (5). pp. 513-515. 10.1016/S0960-894X(00)00027-5 .
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DOI: 10.1016/S0960-894X(00)00027-5
Abstract
The synthesis of a series of new antitumour agents, the benzothiazole substituted quinol ethers and esters, is reported via the hypervalent iodine mediated oxidation of hydroxylated 2-phenylbenzothiazoles. The products were found to be active in vitro against human colon and breast cancer cell lines with IC50 values in the nanomolar range.
| Item Type: | Article |
|---|---|
| Departments, units and centres: | Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry |
| ID Code: | 2364 |
| Journal or Publication Title: | Bioorganic & Medicinal Chemistry Letters |
| Deposited By: | Library Staff |
| Deposited On: | 20 Oct 2011 15:38 |
| Last Modified: | 11 Nov 2011 16:30 |
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