Conservation of gamma-aminobutyric acid type A receptor alpha 6 subunit gene expression in cerebellar granule cells.

Bahn, S., Harvey, R.J., Darlison, M.G. and Wisden, W. (1996) Conservation of gamma-aminobutyric acid type A receptor alpha 6 subunit gene expression in cerebellar granule cells. Journal of Neurochemistry, 66 (5). pp. 1810-1818. 10.1046/j.1471-4159.1996.66051810.x.

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DOI: 10.1046/j.1471-4159.1996.66051810.x

Abstract

The gamma-aminobutyric acid type A receptor cDNAs encoding the alpha 6 subunit homologues from chicken and goldfish have been cloned and sequenced. These proteins exhibit 83 and 75% identity, respectively, to the rat alpha 6 polypeptide. In situ hybridization has demonstrated that, as in mammals, the avian and teleost fish alpha 6 subunit genes are predominantly expressed in cerebellar granule cells. Correspondingly, flunitrazepam-non-displaceable binding of [3H]Ro 15-4513 (a benzodiazepine partial inverse agonist), which is a major characteristic of gamma-aminobutyric acid type-A receptors that contain the alpha 6 polypeptide, is also mainly found for cerebellar granule cells of fish and chick. The conservation of this expression pattern suggests that gamma-aminobutyric acid type A receptors possessing the alpha 6 subunit are of fundamental importance for cerebellar function and that the corresponding gene regulatory elements, e.g., granule cell-specific enhancers, have also been conserved.

Item Type:Article
Uncontrolled Keywords:Teleost fish;Bird;Granule cell;Benzodiazepine;Cerebellum
Departments, units and centres:Department of Pharmacology > Department of Pharmacology
ID Code:2371
Journal or Publication Title:Journal of Neurochemistry
Deposited By:Library Staff
Deposited On:20 Oct 2011 17:57
Last Modified:20 Oct 2011 17:57

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