Bahn, S., Harvey, R.J., Darlison, M.G. and Wisden, W. (1996) Conservation of gamma-aminobutyric acid type A receptor alpha 6 subunit gene expression in cerebellar granule cells. Journal of Neurochemistry, 66 (5). pp. 1810-1818. 10.1046/j.1471-4159.1996.66051810.x.
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The gamma-aminobutyric acid type A receptor cDNAs encoding the alpha 6 subunit homologues from chicken and goldfish have been cloned and sequenced. These proteins exhibit 83 and 75% identity, respectively, to the rat alpha 6 polypeptide. In situ hybridization has demonstrated that, as in mammals, the avian and teleost fish alpha 6 subunit genes are predominantly expressed in cerebellar granule cells. Correspondingly, flunitrazepam-non-displaceable binding of [3H]Ro 15-4513 (a benzodiazepine partial inverse agonist), which is a major characteristic of gamma-aminobutyric acid type-A receptors that contain the alpha 6 polypeptide, is also mainly found for cerebellar granule cells of fish and chick. The conservation of this expression pattern suggests that gamma-aminobutyric acid type A receptors possessing the alpha 6 subunit are of fundamental importance for cerebellar function and that the corresponding gene regulatory elements, e.g., granule cell-specific enhancers, have also been conserved.
|Uncontrolled Keywords:||Teleost fish;Bird;Granule cell;Benzodiazepine;Cerebellum|
|Departments, units and centres:||Department of Pharmacology > Department of Pharmacology|
|Journal or Publication Title:||Journal of Neurochemistry|
|Deposited By:||Library Staff|
|Deposited On:||20 Oct 2011 17:57|
|Last Modified:||20 Oct 2011 17:57|
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