Influence of Aqueous Cream BP on corneocyte size, maturity, skin protease activity, protein content and transepidermal water loss.

Mohammed, D., Matts, P.J., Hadgraft, J. and Lane, M.E. (2011) Influence of Aqueous Cream BP on corneocyte size, maturity, skin protease activity, protein content and transepidermal water loss. British Journal of Dermatology, 164 (6). pp. 1304-1310. 10.1111/j.1365-2133.2011.10338.x.

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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2133.2011.10338.x/pdf

DOI: 10.1111/j.1365-2133.2011.10338.x

Abstract

We report rapid minimally invasive measures of the effects of Aqueous Cream BP at the cellular and molecular level of the skin. Treatment with this formulation is associated with increased desquamatory and inflammatory protease activity. Changes in corneocyte maturity and size are also indicative of accelerated skin turnover induced by chronic application of this emollient. These findings question firmly the routine prescription of this preparation as a moisturizer in patients with atopic dermatitis.

Item Type:Article
Departments, units and centres:Department of Pharmaceutics > Department of Pharmaceutics
ID Code:2384
Journal or Publication Title:British Journal of Dermatology
Deposited By:Library Staff
Deposited On:21 Oct 2011 17:59
Last Modified:21 Oct 2011 17:59

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