Solid-Phase Synthesis of Chlorofusin Analogues

Woon, E.C.Y., Arcieri, M., Wilderspin, A.F., Malkinson, J.P. and Searcey, M. (2007) Solid-Phase Synthesis of Chlorofusin Analogues. Journal of Organic Chemistry, 72 (14). p. 5146. 10.1021/jo070450a.

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DOI: 10.1021/jo070450a


We report an efficient and versatile solid-phase synthesis through which two series of chlorofusin analogues, one bearing varying chromophores and the other with various amino acid substitutions in the cyclic peptide, were synthesized. These peptides were prepared using a strategy involving side-chain immobilization, on-resin cyclization, and postcyclization modification. The success of these syntheses demonstrates the broad utility of the method. Both series of analogues were evaluated for their inhibitory activity against the p53/MDM2 interaction but were shown to be inactive in the concentration range tested. This suggests that the full chromophore structure may be required for activity

Item Type:Article
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry
ID Code:2402
Journal or Publication Title:Journal of Organic Chemistry
Deposited By:Library Staff
Deposited On:03 Nov 2011 17:28
Last Modified:03 Nov 2011 17:28


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