Whitton, P.S., Biggs, C.S., Pearce, B.R. and Fowler, L.J. (1992) Regional effects of MK-801 on dopamine and its metabolites studied by in vivo microdialysis. Neuroscience Letters, 142 (1). pp. 5-8. 10.1016/0304-3940(92)90607-9.
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DOI: 10.1016/0304-3940(92)90607-9
Abstract
The non-competitive N-methyl-D-aspartate receptor antagonist MK-801 was observed to have regionally specific effects on the extracellular concentration of dopamine and its metabolites. In rat anterior striatum, MK-801 transiently decreased extracellular dopamine, in spite of inducing intense circling behaviour which is generally associated with an increase in this neurotransmitter. In contrast, hippocampal extracellular dopamine was increased in a dose-related manner by MK-801. The possible significance of these data is discussed in relation to some of the known behavioural actions of MK-801.
| Item Type: | Article |
|---|---|
| Departments, units and centres: | Department of Pharmacology > Department of Pharmacology |
| ID Code: | 2423 |
| Journal or Publication Title: | Neuroscience Letters |
| Deposited By: | Library Staff |
| Deposited On: | 10 Nov 2011 11:45 |
| Last Modified: | 10 Feb 2012 09:38 |
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