Whitton, P.S., Biggs, C.S., Pearce, B.R. and Fowler, L.J. (1992) Regional effects of MK-801 on dopamine and its metabolites studied by in vivo microdialysis. Neuroscience Letters, 142 (1). pp. 5-8. 10.1016/0304-3940(92)90607-9.
Full text not available from this repository.
The non-competitive N-methyl-D-aspartate receptor antagonist MK-801 was observed to have regionally specific effects on the extracellular concentration of dopamine and its metabolites. In rat anterior striatum, MK-801 transiently decreased extracellular dopamine, in spite of inducing intense circling behaviour which is generally associated with an increase in this neurotransmitter. In contrast, hippocampal extracellular dopamine was increased in a dose-related manner by MK-801. The possible significance of these data is discussed in relation to some of the known behavioural actions of MK-801.
|Departments, units and centres:||Department of Pharmacology > Department of Pharmacology|
|Journal or Publication Title:||Neuroscience Letters|
|Deposited By:||Library Staff|
|Deposited On:||10 Nov 2011 11:45|
|Last Modified:||10 Feb 2012 09:38|
Item downloaded times since 10 Nov 2011 11:45.
Repository Staff Only: Item control page
School of Pharmacy Staff Only: Edit a copy to replace this item