Regional effects of MK-801 on dopamine and its metabolites studied by in vivo microdialysis

Whitton, P.S., Biggs, C.S., Pearce, B.R. and Fowler, L.J. (1992) Regional effects of MK-801 on dopamine and its metabolites studied by in vivo microdialysis. Neuroscience Letters, 142 (1). pp. 5-8. 10.1016/0304-3940(92)90607-9.

Full text not available from this repository.

DOI: 10.1016/0304-3940(92)90607-9

Abstract

The non-competitive N-methyl-D-aspartate receptor antagonist MK-801 was observed to have regionally specific effects on the extracellular concentration of dopamine and its metabolites. In rat anterior striatum, MK-801 transiently decreased extracellular dopamine, in spite of inducing intense circling behaviour which is generally associated with an increase in this neurotransmitter. In contrast, hippocampal extracellular dopamine was increased in a dose-related manner by MK-801. The possible significance of these data is discussed in relation to some of the known behavioural actions of MK-801.

Item Type:Article
Departments, units and centres:Department of Pharmacology > Department of Pharmacology
ID Code:2423
Journal or Publication Title:Neuroscience Letters
Deposited By:Library Staff
Deposited On:10 Nov 2011 11:45
Last Modified:10 Feb 2012 09:38

Repository Staff Only: Item control page

School of Pharmacy Staff Only: Edit a copy to replace this item