Tetanus Toxin Inhibition of K+ -Stimulated [3H]GABA Release from Developing Cell Cultures of the Rat Cerebellum

Pearce, B.R., Gard, A.L. and Dutton, G.R. (1983) Tetanus Toxin Inhibition of K+ -Stimulated [3H]GABA Release from Developing Cell Cultures of the Rat Cerebellum. Journal of Neurochemistry, 40 (3). pp. 887-890. 10.1111/j.1471-4159.1983.tb08064.x.

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DOI: 10.1111/j.1471-4159.1983.tb08064.x

Abstract

The effect of tetanus toxin pretreatment on K+-stimulated [3H]gamma-aminobutyric acid release from neuron-enriched cerebellar cell cultures at various stages during their development in vitro was assessed. Tetanus toxin had little inhibitory effect on immature (1-3-day-old) cultures, but markedly reduced K+-evoked [3H]gamma-aminobutyric acid release from 7- and 14-day-old cultures (approximately 80% inhibition). It is suggested that cerebellar neurons in culture develop tetanus toxin-sensitive transmitter release mechanisms similar to their in vivo counterparts.

Item Type:Article
Departments, units and centres:Department of Pharmacology > Department of Pharmacology
ID Code:2430
Journal or Publication Title:Journal of Neurochemistry
Deposited By:Library Staff
Deposited On:10 Nov 2011 14:24
Last Modified:10 Nov 2011 14:24

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