L-glutamate increases the spontaneous release of [3H]GABA from cultured cerebellar neurons. (Short communication)

Pearce, B.R. and Dutton, G.R. (1982) L-glutamate increases the spontaneous release of [3H]GABA from cultured cerebellar neurons. (Short communication). Brain Research, 255 (3). pp. 492-496. 10.1016/0165-3806(82)90015-3.

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DOI: 10.1016/0165-3806(82)90015-3

Abstract

The effects of l-glutamate on the spontaneousrelease of [3H]GABA from cerebellar neurons in well characterized cerebellar monolayer cultures were investigated. The release process was dependent on Ca2+, elicited by neuronal depolarization and specific to l-glutamate. d-Glutamate and l-aspartate were without effect, and glutamic acid diethylester (GDEE) abolished l-glutamate stimulated 3H]GABA release, suggesting that this effect was mediated by glutamate receptors

Item Type:Article
Uncontrolled Keywords:spontaneous transmitter release; GABA; cerebellum; glutamate; primary neuronal cultures
Departments, units and centres:Department of Pharmacology > Department of Pharmacology
ID Code:2432
Journal or Publication Title:Brain Research
Deposited By:Library Staff
Deposited On:10 Nov 2011 14:34
Last Modified:10 Nov 2011 14:34

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