Potassium-stimulated, calcium-dependent release of [3H]GABA from neuron- and glia-enriched cultures of cells dissociated from rat cerebellum

Pearce, B.R., Currie, D.N., Beale, R. and Dutton, G.R. (1981) Potassium-stimulated, calcium-dependent release of [3H]GABA from neuron- and glia-enriched cultures of cells dissociated from rat cerebellum. Brain Research, 206 (2). pp. 485-489. 10.1016/0006-8993(81)90552-7.

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DOI: 10.1016/0006-8993(81)90552-7

Abstract

The release of [3H]GABA from cultures of cells dissociated from the rat cerebellum was investigated. The culture system contained a population of neurons (stellate and basket cells) which were capable of accumulating [3H]GABA and releasing it in a calcium-dependent manner in response to 50 mM potassium. In addition, the release of [3H]GABA for cultured astrocytes was found to be insensitive to potassium depolarization.

Item Type:Article
Uncontrolled Keywords:transmitter release; GABA; cell cultures; dissociated cells; cerebellum
Departments, units and centres:Department of Pharmacology > Department of Pharmacology
ID Code:2435
Journal or Publication Title:Brain Research
Deposited By:Library Staff
Deposited On:10 Nov 2011 14:48
Last Modified:10 Nov 2011 14:48

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