Polyhedral non-ionic surfactant vesicles.

Uchegbu, I.F., Schatzlein, A.G., Vanlerberghe, G., Morgatini, N. and Florence, A.T. (1997) Polyhedral non-ionic surfactant vesicles. Journal of Pharmacy and Pharmacology, 49 (6). pp. 606-610. 10.1111/j.2042-7158.1997.tb06853.x.

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DOI: 10.1111/j.2042-7158.1997.tb06853.x


Large polyhedral (2-10 microns) non-ionic surfactant vesicles (niosomes) formed from mixtures of a hexadecyl diglycerol ether (C16G2), a cholesteryl poly-24-oxyethylene ether (solulan C24) and a low level of cholesterol are being investigated as slow-release systems for ophthalmic, subcutaneous or intramuscular administration. The phase-diagram of this three-component system has been constructed and these polyhedral vesicles are found to be in the gel (L beta) phase. Confocal laser-scanning microscopy was used to confirm the complex morphology of these vesicles. The thermo-responsive nature of release of entrapped carboxyfluorescein and nicotinamide adenine dinucleotide has been studied; release is increased with increase in temperature (37 degrees C) even though the polyhedral vesicles still maintain their polyhedral shape at this temperature. The results indicate that the thermo-responsive features of the niosomes are a result of reversible changes in bi-layer permeability caused by temperature-mediated alteration in the membrane-packing characteristics of the polyethoxylated cholesterol ether.

Item Type:Article
Departments, units and centres:Department of Pharmaceutics > Department of Pharmaceutics
ID Code:2441
Journal or Publication Title:Journal of Pharmacy and Pharmacology
Deposited By:Library Staff
Deposited On:10 Nov 2011 16:34
Last Modified:10 Nov 2011 16:34


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