GABAA Receptors at Hippocampal Mossy Fibers

Ruiz, A., Fabian-Fine, R., Scott, R., Walker, M.C., Rusakov, D.A. and Kullmann, D.M. (2003) GABAA Receptors at Hippocampal Mossy Fibers. Neuron, 39 (6). pp. 961-973. 10.1016/S0896-6273(03)00559-2.

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DOI: 10.1016/S0896-6273(03)00559-2


Presynaptic GABAA receptors modulate synaptic transmission in several areas of the CNS but are not known to have this action in the cerebral cortex. We report that GABAA receptor activation reduces hippocampal mossy fibers excitability but has the opposite effect when intracellular Cl is experimentally elevated. Synaptically released GABA mimics the effect of exogenous agonists. GABAA receptors modulating axonal excitability are tonically active in the absence of evoked GABA release or exogenous agonist application. Presynaptic action potential-dependent Ca2+ transients in individual mossy fiber varicosities exhibit a biphasic dependence on membrane potential and are altered by GABAA receptors. Antibodies against the α2 subunit of GABAA receptors stain mossy fibers. Axonal GABAA receptors thus play a potentially important role in tonic and activity-dependent heterosynaptic modulation of information flow to the hippocampus.

Item Type:Article
Departments, units and centres:Department of Pharmacology > Department of Pharmacology
ID Code:2451
Journal or Publication Title:Neuron
Deposited By:Library Staff
Deposited On:11 Nov 2011 10:34
Last Modified:11 Nov 2011 10:34


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