Shannon, K.P., Stapleton, P.D., Xiang, X., Johnson, A., Beattie, H., El Bakri, F., Cookson, B. and French, G.L. (1998) Extended-Spectrum β-Lactamase-Producing Klebsiella pneumoniae Strains Causing Nosocomial Outbreaks of Infection in the United Kingdom. Journal of Clinical Microbiology, 36 (10). pp. 3105-3110.
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Representative isolates from 10 distinct extended-spectrum β-lactamase-producing strains of Klebsiella pneumoniaethat caused hospital outbreaks in the United Kingdom from 1991 to 1994 were examined for relationships between their enzymes and plasmids. The β-lactamases were identified by a combination of isoelectric focusing and gene sequencing. SHV-2 β-lactamase was produced by isolates from four outbreaks, SHV-5 was involved in three, and SHV-4, TEM-15, and TEM-26 were involved in one outbreak each. All of the extended-spectrum β-lactamases were encoded by self-transmissible plasmids, with sizes ranging from about 70 to 160 kb. No similarities between the restriction digest patterns of the extended-spectrum β-lactamase-encoding plasmids were detected, except to some extent between those that produced TEM-15 and TEM-26. Thus, outbreaks of hospital infection with these organisms in the United Kingdom from 1991 to 1994 involved distinct organisms and resistance plasmids and appeared to be unrelated.
|Departments, units and centres:||Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry|
|Journal or Publication Title:||Journal of Clinical Microbiology|
|Deposited By:||Library Staff|
|Deposited On:||18 Nov 2011 15:48|
|Last Modified:||18 Nov 2011 15:48|
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