Extended-Spectrum β-Lactamase-Producing Klebsiella pneumoniae Strains Causing Nosocomial Outbreaks of Infection in the United Kingdom

Shannon, K.P., Stapleton, P.D., Xiang, X., Johnson, A., Beattie, H., El Bakri, F., Cookson, B. and French, G.L. (1998) Extended-Spectrum β-Lactamase-Producing Klebsiella pneumoniae Strains Causing Nosocomial Outbreaks of Infection in the United Kingdom. Journal of Clinical Microbiology, 36 (10). pp. 3105-3110.

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Abstract

Representative isolates from 10 distinct extended-spectrum β-lactamase-producing strains of Klebsiella pneumoniaethat caused hospital outbreaks in the United Kingdom from 1991 to 1994 were examined for relationships between their enzymes and plasmids. The β-lactamases were identified by a combination of isoelectric focusing and gene sequencing. SHV-2 β-lactamase was produced by isolates from four outbreaks, SHV-5 was involved in three, and SHV-4, TEM-15, and TEM-26 were involved in one outbreak each. All of the extended-spectrum β-lactamases were encoded by self-transmissible plasmids, with sizes ranging from about 70 to 160 kb. No similarities between the restriction digest patterns of the extended-spectrum β-lactamase-encoding plasmids were detected, except to some extent between those that produced TEM-15 and TEM-26. Thus, outbreaks of hospital infection with these organisms in the United Kingdom from 1991 to 1994 involved distinct organisms and resistance plasmids and appeared to be unrelated.

Item Type:Article
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry
ID Code:2474
Journal or Publication Title:Journal of Clinical Microbiology
Deposited By:Library Staff
Deposited On:18 Nov 2011 15:48
Last Modified:18 Nov 2011 15:48

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