Groc, L., Heine, M., Cognet, L., Brickley, K., Stephenson, F.A., Lounis, B. and Choquet, D. (2004) Differential activity-dependent regulation of the lateral mobilities of AMPA and NMDA receptors. Nature Neuroscience, 7 (7). pp. 695-696. 10.1038/nn1270.
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The basis for differences in activity-dependent trafficking of AMPA receptors (AMPARs) and NMDA receptors (NMDARs) remains unclear. Using single-molecule tracking, we found different lateral mobilities for AMPARs and NMDARs: changes in neuronal activity modified AMPAR but not NMDAR mobility, whereas protein kinase C activation modified both. Differences in mobility were mainly detected for extrasynaptic AMPARs, suggesting that receptor diffusion between synaptic and extrasynaptic domains is involved in plasticity processes.
|Departments, units and centres:||Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry|
|Journal or Publication Title:||Nature Neuroscience|
|Deposited By:||Library Staff|
|Deposited On:||24 Nov 2011 10:05|
|Last Modified:||24 Nov 2011 10:05|
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