Differential activity-dependent regulation of the lateral mobilities of AMPA and NMDA receptors

Groc, L., Heine, M., Cognet, L., Brickley, K., Stephenson, F.A., Lounis, B. and Choquet, D. (2004) Differential activity-dependent regulation of the lateral mobilities of AMPA and NMDA receptors. Nature Neuroscience, 7 (7). pp. 695-696. 10.1038/nn1270.

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DOI: 10.1038/nn1270

Abstract

The basis for differences in activity-dependent trafficking of AMPA receptors (AMPARs) and NMDA receptors (NMDARs) remains unclear. Using single-molecule tracking, we found different lateral mobilities for AMPARs and NMDARs: changes in neuronal activity modified AMPAR but not NMDAR mobility, whereas protein kinase C activation modified both. Differences in mobility were mainly detected for extrasynaptic AMPARs, suggesting that receptor diffusion between synaptic and extrasynaptic domains is involved in plasticity processes.

Item Type:Article
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry
ID Code:2492
Journal or Publication Title:Nature Neuroscience
Deposited By:Library Staff
Deposited On:24 Nov 2011 10:05
Last Modified:24 Nov 2011 10:05

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