Trans-ACPD induces a slow post-stimulus inward tail current (IADP) in guinea-pig olfactory cortex neurones in vitro.

Constanti, A. and Libri, V. (1992) Trans-ACPD induces a slow post-stimulus inward tail current (IADP) in guinea-pig olfactory cortex neurones in vitro. European Journal of Pharmacology, 216 (3). pp. 463-464. 10.1016/0014-2999(92)90450-I.

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DOI: 10.1016/0014-2999(92)90450-I

Abstract

The metabotropic glutamate receptor agonist trans-(+/-)-1-amino-1,3-cyclopentanedicarboxylic acid (trans-ACPD) produced a slow, persistent excitation of guinea-pig olfactory cortical neurones in vitro, and the appearance of a prominent post-stimulus after depolarization. The corresponding slow inward tail current (IADP) revealed under voltage clamp was insensitive to tetrodotoxin (or atropine) but was blocked by Cd2+ or tetrabutylammonium. The IADP properties resembled those of the slow inward tail current induced by muscarinic agonists in these neurones, suggesting a common intracellular transduction mechanism.

Item Type:Article
Departments, units and centres:Department of Pharmacology > Department of Pharmacology
ID Code:2527
Journal or Publication Title:European Journal of Pharmacology
Deposited By:Library Staff
Deposited On:25 Nov 2011 09:46
Last Modified:25 Nov 2011 09:46

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