Constanti, A. and Libri, V. (1992) Trans-ACPD induces a slow post-stimulus inward tail current (IADP) in guinea-pig olfactory cortex neurones in vitro. European Journal of Pharmacology, 216 (3). pp. 463-464. 10.1016/0014-2999(92)90450-I.
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DOI: 10.1016/0014-2999(92)90450-I
Abstract
The metabotropic glutamate receptor agonist trans-(+/-)-1-amino-1,3-cyclopentanedicarboxylic acid (trans-ACPD) produced a slow, persistent excitation of guinea-pig olfactory cortical neurones in vitro, and the appearance of a prominent post-stimulus after depolarization. The corresponding slow inward tail current (IADP) revealed under voltage clamp was insensitive to tetrodotoxin (or atropine) but was blocked by Cd2+ or tetrabutylammonium. The IADP properties resembled those of the slow inward tail current induced by muscarinic agonists in these neurones, suggesting a common intracellular transduction mechanism.
| Item Type: | Article |
|---|---|
| Departments, units and centres: | Department of Pharmacology > Department of Pharmacology |
| ID Code: | 2527 |
| Journal or Publication Title: | European Journal of Pharmacology |
| Deposited By: | Library Staff |
| Deposited On: | 25 Nov 2011 09:46 |
| Last Modified: | 25 Nov 2011 09:46 |
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