Muscarinic suppression of the evoked N-wave by oxotremorine-M recorded in the guinea-pig olfactory cortex slice.

Bagetta, G. and Constanti, A. (1990) Muscarinic suppression of the evoked N-wave by oxotremorine-M recorded in the guinea-pig olfactory cortex slice. European Journal of Pharmacology, 178 (1). pp. 91-96. 10.1016/0014-2999(90)94797-2.

Full text not available from this repository.

DOI: 10.1016/0014-2999(90)94797-2

Abstract

The effect of the muscarinic agonist oxotremorine-M has been studied on the surface-negative field potential (N-wave) evoked by orthodromic stimulation of the lateral olfactory tract in slices of guinea-pig olfactory cortex. Bath-application of oxotremorine-M (5-80 microM) or carbachol (10-300 microM) produced a reversible depression of the N-wave amplitude without affecting the lateral olfactory tract compound action potential. Oxotremorine-M was approximately 5 times more potent than carbachol in this respect, and the effects of both agonists were competitively blocked by telenzepine (5-100 nM), a selective M1-receptor antagonist. In contrast, methoctramine or AF-DX 116, two 'cardioselective' M2-receptor antagonists, had little or no blocking effect on the agonist responses. It is suggested that oxotremorine-M (like carbachol) inhibits the evoked field potential by activating presynaptic M1-type muscarinic receptors in the olfactory cortex slice.

Item Type:Article
Uncontrolled Keywords:Oxotremorine-M; Olfactory cortex slice; Surface field potential (N-wave); Muscarinic receptors; (Guinea-pig)
Departments, units and centres:Department of Pharmacology > Department of Pharmacology
ID Code:2534
Journal or Publication Title:European Journal of Pharmacology
Deposited By:Library Staff
Deposited On:25 Nov 2011 10:03
Last Modified:25 Nov 2011 10:03

Repository Staff Only: Item control page

School of Pharmacy Staff Only: Edit a copy to replace this item