Bagetta, G. and Constanti, A. (1990) Muscarinic suppression of the evoked N-wave by oxotremorine-M recorded in the guinea-pig olfactory cortex slice. European Journal of Pharmacology, 178 (1). pp. 91-96. 10.1016/0014-2999(90)94797-2.
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The effect of the muscarinic agonist oxotremorine-M has been studied on the surface-negative field potential (N-wave) evoked by orthodromic stimulation of the lateral olfactory tract in slices of guinea-pig olfactory cortex. Bath-application of oxotremorine-M (5-80 microM) or carbachol (10-300 microM) produced a reversible depression of the N-wave amplitude without affecting the lateral olfactory tract compound action potential. Oxotremorine-M was approximately 5 times more potent than carbachol in this respect, and the effects of both agonists were competitively blocked by telenzepine (5-100 nM), a selective M1-receptor antagonist. In contrast, methoctramine or AF-DX 116, two 'cardioselective' M2-receptor antagonists, had little or no blocking effect on the agonist responses. It is suggested that oxotremorine-M (like carbachol) inhibits the evoked field potential by activating presynaptic M1-type muscarinic receptors in the olfactory cortex slice.
|Uncontrolled Keywords:||Oxotremorine-M; Olfactory cortex slice; Surface field potential (N-wave); Muscarinic receptors; (Guinea-pig)|
|Departments, units and centres:||Department of Pharmacology > Department of Pharmacology|
|Journal or Publication Title:||European Journal of Pharmacology|
|Deposited By:||Library Staff|
|Deposited On:||25 Nov 2011 10:03|
|Last Modified:||25 Nov 2011 10:03|
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