Expression of NMDAR1-1a (N598Q)/NMDAR2A receptors results in decreased cell mortality.

Cik, M., Chazot, P.L. and Stephenson, F.A. (1994) Expression of NMDAR1-1a (N598Q)/NMDAR2A receptors results in decreased cell mortality. European Journal of Pharmacology, 266 (3). R1-3. 10.1016/0922-4106(94)90146-5.

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DOI: 10.1016/0922-4106(94)90146-5

Abstract

Transient expression of wild-type N-methyl-D-aspartate, NMDAR1-1a/NMDAR2A heteromeric receptors, in mammalian cells yields cell death which was prevented by the inclusion of NMDA receptor antagonists in the cell culture media post-transfection. Transient expression of mutant NMDAR1-1a (N598Q)/NMDAR2A receptors resulted in a significant decrease in the percentage of cell death post-transfection. This mutation has been shown to reduce the Ca2+ permeability of cloned NMDA receptors. Thus these results provide indirect evidence for cell death via an NMDA receptor, Ca(2+)-mediated mechanism.

Item Type:Article
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry
ID Code:2570
Journal or Publication Title:European Journal of Pharmacology
Deposited By:Library Staff
Deposited On:25 Nov 2011 15:34
Last Modified:25 Nov 2011 15:34

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