Mapping of GABAA receptor alpha 5 and alpha 6 subunit-like immunoreactivity in rat brain.

Thompson, C.L., Bodewitz, G., Stephenson, F.A. and Turner, J.D (1992) Mapping of GABAA receptor alpha 5 and alpha 6 subunit-like immunoreactivity in rat brain. Neuroscience Letters, 144 (1-2). pp. 53-56. 10.1016/0304-3940(92)90714-I.

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DOI: 10.1016/0304-3940(92)90714-I

Abstract

The distribution of the alpha 5 and alpha 6 subunits of the GABAA receptor has been mapped in rat brain using affinity-purified antibodies generated against peptide sequences unique to the respective polypeptides. alpha 5 Subunit-like immunoreactivity was of low density but was distributed across several cell groups including cortical interneurones, hippocampal CA3 pyramidal neurones, the anterior thalamic reticular nucleus and cerebellar Purkinje neurones. alpha 6 Subunit-like immunoreactivity was observed in high density in cerebellar granule cells. These patterns are compatible with in situ hybridisation studies and provide a further anatomical substrate for GABAA receptor heterogeneity in the CNS.

Item Type:Article
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry
ID Code:2578
Journal or Publication Title:Neuroscience Letters
Deposited By:Library Staff
Deposited On:25 Nov 2011 16:13
Last Modified:25 Nov 2011 16:13

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