Thompson, C.L., Bodewitz, G., Stephenson, F.A. and Turner, J.D (1992) Mapping of GABAA receptor alpha 5 and alpha 6 subunit-like immunoreactivity in rat brain. Neuroscience Letters, 144 (1-2). pp. 53-56. 10.1016/0304-3940(92)90714-I.
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DOI: 10.1016/0304-3940(92)90714-I
Abstract
The distribution of the alpha 5 and alpha 6 subunits of the GABAA receptor has been mapped in rat brain using affinity-purified antibodies generated against peptide sequences unique to the respective polypeptides. alpha 5 Subunit-like immunoreactivity was of low density but was distributed across several cell groups including cortical interneurones, hippocampal CA3 pyramidal neurones, the anterior thalamic reticular nucleus and cerebellar Purkinje neurones. alpha 6 Subunit-like immunoreactivity was observed in high density in cerebellar granule cells. These patterns are compatible with in situ hybridisation studies and provide a further anatomical substrate for GABAA receptor heterogeneity in the CNS.
| Item Type: | Article |
|---|---|
| Departments, units and centres: | Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry |
| ID Code: | 2578 |
| Journal or Publication Title: | Neuroscience Letters |
| Deposited By: | Library Staff |
| Deposited On: | 25 Nov 2011 16:13 |
| Last Modified: | 25 Nov 2011 16:13 |
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