Antiprotozoal, antimycobacterial and cytotoxic potential of twenty-three British and Irish red algae.

Allmendinger, A., Spavieri, J., Kaiser, M., Casey, R., Hingley-Wilson, S., Lalvani, A., Guiry, M.D., Blunden, G. and Tasdemir, D. (2010) Antiprotozoal, antimycobacterial and cytotoxic potential of twenty-three British and Irish red algae. Phytotherapy Research, 24 (7). pp. 1099-1103. 10.1002/ptr.3094.

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DOI: 10.1002/ptr.3094

Abstract

As part of our continuing research on seaweeds, we have screened the crude extracts of 23 red marine algae collected from England and Ireland. The clinically important blood-stage life forms of Trypanosoma brucei rhodesiense, T. cruzi, Leishmania donovani and Mycobacterium tuberculosis were used as test organisms in the in vitro assays. The selectivity of the extracts was determined by using mammalian skeletal myoblast (L6) cells. All algal extracts showed activity against T. brucei rhodesiense, with Corallina officinalis and Ceramium virgatum being the most potent (IC(50) values 4.8 and 5.4 microg/ml), whilst none of the algal extracts inhibited the growth of T. cruzi. Except for Porphyra leucosticta, extracts from all seaweeds also showed leishmanicidal activity with IC(50) values ranging from 16.5 to 85.6 microg/ml. Only the crude extract of Calliblepharis jubata showed some weak activity against Mycobacterium tuberculosis (MIC value 256 microg/ml), while the others were inactive at this concentration. Corallina officinalis was the only seaweed that displayed some marginal cytotoxicity (IC(50) value 88.6 microg/ml), and all remaining extracts were non-toxic towards L6 cells at 90 microg/ml concentration. To our knowledge, this is the first study reporting antiprotozoal and antimycobacterial activity of British and Irish red algae.

Item Type:Article
Uncontrolled Keywords:Marine red algae; Trypanosoma; Leishmania; Mycobacterium; cytotoxicity
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry
ID Code:2587
Journal or Publication Title:Phytotherapy Research
Deposited By:Library Staff
Deposited On:25 Nov 2011 17:57
Last Modified:01 Dec 2011 16:50

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