Karioti, A., Skaltsa, H., Linden, A., Perozzo, R., Brun, R. and Tasdemir, D. (2007) Anthecularin: A Novel Sesquiterpene Lactone fromAnthemis auriculatawith Antiprotozoal Activity. Journal of Organic Chemistry, 72 (21). pp. 8103-8106. 10.1021/jo701751w.
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DOI: 10.1021/jo701751w
Abstract
Anthecularin (1), a minor sesquiterpene lactone with a novel ring system was isolated from Greek Anthemis auriculata (Asteraceae). Its structure was elucidated by means of NMR, HRMS, and X-ray crystallography. Anthecularin showed antitrypanosomal (IC50=10.1 microg/mL) and antiplasmodial activity (IC50=23.3 microg/mL) and inhibited two key enzymes of the plasmodial type II fatty acid biosynthesis pathway, PfFabI and PfFabG (IC50 values=14 and 28.3 microg/mL, respectively). A probable biogenesis of 1 is also proposed and discussed.
| Item Type: | Article |
|---|---|
| Departments, units and centres: | Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry |
| ID Code: | 2594 |
| Journal or Publication Title: | Journal of Organic Chemistry |
| Deposited By: | Library Staff |
| Deposited On: | 02 Dec 2011 08:59 |
| Last Modified: | 02 Dec 2011 08:59 |
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