Anthecularin:  A Novel Sesquiterpene Lactone fromAnthemis auriculatawith Antiprotozoal Activity

Karioti, A., Skaltsa, H., Linden, A., Perozzo, R., Brun, R. and Tasdemir, D. (2007) Anthecularin:  A Novel Sesquiterpene Lactone fromAnthemis auriculatawith Antiprotozoal Activity. Journal of Organic Chemistry, 72 (21). pp. 8103-8106. 10.1021/jo701751w.

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DOI: 10.1021/jo701751w

Abstract

Anthecularin (1), a minor sesquiterpene lactone with a novel ring system was isolated from Greek Anthemis auriculata (Asteraceae). Its structure was elucidated by means of NMR, HRMS, and X-ray crystallography. Anthecularin showed antitrypanosomal (IC50=10.1 microg/mL) and antiplasmodial activity (IC50=23.3 microg/mL) and inhibited two key enzymes of the plasmodial type II fatty acid biosynthesis pathway, PfFabI and PfFabG (IC50 values=14 and 28.3 microg/mL, respectively). A probable biogenesis of 1 is also proposed and discussed.

Item Type:Article
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry
ID Code:2594
Journal or Publication Title:Journal of Organic Chemistry
Deposited By:Library Staff
Deposited On:02 Dec 2011 08:59
Last Modified:02 Dec 2011 08:59

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