Anderson, J.C., McCarthy, R.A., Paulin, S. and Taylor, P.W. (2011) Anti-staphylococcal activity and β-lactam resistance attenuating capacity of structural analogues of (−)-epicatechin gallate. Bioorganic & Medicinal Chemistry Letters, 21 (23). pp. 6996-7000. 10.1016/j.bmcl.2011.09.116.
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We examined the impact of gradual removal of hydroxyl groups from the A- and B-rings of (−)-epicatechin gallate on antibacterial activity and oxacillin resistance attenuation of an epidemic strain of methicillin resistant Staphylococcusaureus. Removal of both hydroxyls from the B-ring effected a large reduction in oxacillin MIC (from 512 to 0.25 mg/mL at a concentration of 12.5 mg/L); further hydroxyl deletion of the A-ring reduced the oxacillin effect but increased intrinsic anti-staphylococcal activity
|Uncontrolled Keywords:||MRSA; (−)-Epicatechin gallate analogues; β-Lactam antibiotics; Antibacterial chemotherapy; Antibiotic resistance|
|Departments, units and centres:||Department of Pharmaceutics > Department of Pharmaceutics|
|Journal or Publication Title:||Bioorganic & Medicinal Chemistry Letters|
|Deposited By:||Library Staff|
|Deposited On:||02 Dec 2011 17:42|
|Last Modified:||02 Dec 2011 17:42|
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