Anti-staphylococcal activity and β-lactam resistance attenuating capacity of structural analogues of (−)-epicatechin gallate

Anderson, J.C., McCarthy, R.A., Paulin, S. and Taylor, P.W. (2011) Anti-staphylococcal activity and β-lactam resistance attenuating capacity of structural analogues of (−)-epicatechin gallate. Bioorganic & Medicinal Chemistry Letters, 21 (23). pp. 6996-7000. 10.1016/j.bmcl.2011.09.116.

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DOI: 10.1016/j.bmcl.2011.09.116

Abstract

We examined the impact of gradual removal of hydroxyl groups from the A- and B-rings of (−)-epicatechin gallate on antibacterial activity and oxacillin resistance attenuation of an epidemic strain of methicillin resistant Staphylococcusaureus. Removal of both hydroxyls from the B-ring effected a large reduction in oxacillin MIC (from 512 to 0.25 mg/mL at a concentration of 12.5 mg/L); further hydroxyl deletion of the A-ring reduced the oxacillin effect but increased intrinsic anti-staphylococcal activity

Item Type:Article
Uncontrolled Keywords:MRSA; (−)-Epicatechin gallate analogues; β-Lactam antibiotics; Antibacterial chemotherapy; Antibiotic resistance
Departments, units and centres:Department of Pharmaceutics > Department of Pharmaceutics
ID Code:2623
Journal or Publication Title:Bioorganic & Medicinal Chemistry Letters
Deposited By:Library Staff
Deposited On:02 Dec 2011 17:42
Last Modified:02 Dec 2011 17:42

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