Biocytin-labelling and its impact on late 20th century studies of cortical circuitry

Thomson, A.M. and Armstrong, W.E. (2011) Biocytin-labelling and its impact on late 20th century studies of cortical circuitry. Brain Research Reviews, 66 (1-2). pp. 43-63. 10.1016/j.brainresrev.2010.04.004.

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DOI: 10.1016/j.brainresrev.2010.04.004


In recognition of the impact that a powerful new anatomical tool, such as the Golgi method, can have, this essay highlights the enormous influence that biocytin-filling has had on modern neuroscience. This method has allowed neurones that have been recorded intracellularly, ‘whole-cell’ or juxta-cellularly, to be identified anatomically, forming a vital link between functional and structural studies. It has been applied throughout the nervous system and has become a fundamental component of our technical armoury. A comprehensive survey of the applications to which the biocytin-filling approach has been put, would fill a large volume. This essay therefore focusses on one area, neocortical microcircuitry and the ways in which combining physiology and anatomy have revealed rules that help us explain its previously indecipherable variability and complexity.

Item Type:Article
Uncontrolled Keywords:Biocytin; Interneurone; Cortex; Circuitry; Hypothalamo-neurohypophysial system; Dual recording
Departments, units and centres:Department of Pharmacology > Department of Pharmacology
ID Code:2637
Journal or Publication Title:Brain Research Reviews
Deposited By:Library Staff
Deposited On:12 Jan 2012 15:57
Last Modified:12 Jan 2012 15:57

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