A local circuit neocortical synapse that operates via both NMDA and non-NMDA receptors

Thomson, A.M., Girdlestone, D. and West, D.C. (1989) A local circuit neocortical synapse that operates via both NMDA and non-NMDA receptors. British Journal of Pharmacology, 96 . pp. 406-408.

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Official URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1854375/pdf/brjpharm00274-0158.pdf

Abstract

1 In slices of rat neocortex, spike triggered averaging was employed to record in one neurone the excitatory postsynaptic potential (e.p.s.p.) generated by a spike in another, neighbouring neurone. When recorded at different membrane potentials, some of these e.p.s.ps exhibited a voltage relation typical of neuronal responses to N-methyl-D-aspartate (NMDA). 2 Selective NMDA antagonists reduced the amplitude of these e.p.s.ps, but had little effect on their early rising phase. In contrast, a less selective excitatory amino acid antagonist reduced all phases of the e.p.s.p. 3 By analyzing single axon e.p.s.ps we have been able to establish that the synaptic input to one cortical cell, delivered by a single presynaptic cortical cell, operates simultaneously via NMDA and non-NMDA amino acid receptors.

Item Type:Article
Departments, units and centres:Department of Pharmacology > Department of Pharmacology
ID Code:2668
Journal or Publication Title:British Journal of Pharmacology
Deposited By:Library Staff
Deposited On:13 Jan 2012 17:39
Last Modified:13 Jan 2012 17:39

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