Ceramide as an activator lipid of cathepsin D.

Heinrich, M., Wickel, M., Winoto-Morbach, S., Schneider-Brachert, W, Weber, T., Brunner, J., Saftig, P., Petersen, C.C., Krönke, M. and Schütze, S. (2000) Ceramide as an activator lipid of cathepsin D. Advances in Experimental Medicine and Biology, 477 . pp. 305-315.

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We have identified the aspartic protease cathepsin D as a novel intracellular target protein for the lipid second messenger ceramide. Ceramide specifically binds to and induces CTSD proteolytic activity. A-SMase deficient cells derived from Niemann-Pick patients show decreased CTSD activity that was reconstituted by transfection with A-SMase cDNA. Ceramide accumulation in cells derived from A-ceramidase defective Farber patients correlates with enhanced CTSD activity. These findings suggest that A-SMase-derived ceramide targets endolysosomal CTSD.

Item Type:Article
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Centre for Pharmacognosy and Phytotherapy
ID Code:2695
Journal or Publication Title:Advances in Experimental Medicine and Biology
Deposited By:Library Staff
Deposited On:19 Jan 2012 16:29
Last Modified:19 Jan 2012 16:29


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