Phytochemical and Biological Investigation ofBegonia heracleifolia

Frei, B., Heinrich, M., Herrmann, D., Orjala, J., Schmitt, J. and Sticher, O. (1998) Phytochemical and Biological Investigation ofBegonia heracleifolia. Planta Medica, 64 (04). pp. 385-386. 10.1055/s-2006-957460.

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DOI: 10.1055/s-2006-957460


From the rhizomes of Begonia heracleifolia six known cucurbitacins (1-6) were isolated. Based on spectral data (1D and 2D1H-, 13C-NMR, ESI- and CI-MS) the structures were established as cucurbitacin B (1), cucurbitacin D (2), 23,24-dihydrocucurbitacin D (3), 23,24-dihydrocucurbitacin F (4), 2-O-β-glucopyranosyl-cucurbitacin B (5), and 2-O-β-glucopyranosyl-cucurbitacin D (6). Four of them (3-6) were so far not reported as constituents of Begonia spp. Varyingly strong antiproliferative activity towards tumor and immune cells was observed for three compounds (1 -3), due to different structural features.

Item Type:Article
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Centre for Pharmacognosy and Phytotherapy
ID Code:2701
Journal or Publication Title:Planta Medica
Deposited By:Library Staff
Deposited On:19 Jan 2012 17:41
Last Modified:19 Jan 2012 17:41


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