Antibacterial hydroperoxysterols from Xanthosoma robustum.

Kato, T., Frei, B., Heinrich, M. and Sticher, O. (1996) Antibacterial hydroperoxysterols from Xanthosoma robustum. Phytochemistry, 41 (4). pp. 1191-1195. 10.1016/0031-9422(95)00765-2.

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DOI: 10.1016/0031-9422(95)00765-2

Abstract

Three new hydroperoxysterols, 24-hydroperoxy-4 alpha, 14 alpha- dimethylcholesta-8,25-dien-3 beta-ol, 25-hydroperoxy-4 alpha, 14 alpha-dimethylcholesta-8,23-dien-3 beta-ol and 25-hydroperoxycycloart-23-en- 3 beta-ol, have been isolated from the aerial parts of Xanthosoma robustum, besides 24-hydroperoxycycloart-25-en-3 beta-ol, 4 alpha, 14 alpha-dimethylcholesta-8,24-dien-3 beta-ol and cycloartenol. Additionally, the two new diols, 4 alpha, 14 alpha-dimethylcholesta-8,25-dien-3 beta, 24-diol and 4 alpha, 14 alpha-dimethylcholesta-8,23-dien-3 beta, 25-diol were obtained from the first two hydroperoxysterols, respectively, by reduction with triphenylphosphine. The structures have been defined by chemical and spectroscopic studies. The four hydroperoxysterols exhibited antibacterial activities against Escherichia coli, Bacillus subtilis and Micrococcus luteus.

Item Type:Article
Uncontrolled Keywords: Xanthosoma robustum; Araceae; hydroperoxides; antibacterial activity; 24-hydroperoxy-4α,14α-dimethylcholesta-8,26-dien-3β-ol; 25-hydroperoxy-4α,14α-dimethylcholesta-8,23-dien-3β-ol; 25-hydroperoxycycloart-23-en-3β-ol; 24-hydroperoxycycloart-25-en-3β-ol; 4α,14α-dimethylcholesta-8,24-dien-3β-ol; cycloartenol
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Centre for Pharmacognosy and Phytotherapy
ID Code:2705
Journal or Publication Title:Phytochemistry
Deposited By:Library Staff
Deposited On:20 Jan 2012 09:23
Last Modified:20 Jan 2012 09:23

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