Tanzanian medicinal plants used traditionally for the treatment of malaria:In vivo antimalarial andin vitro cytotoxic activities

Gessler, M.C., Tanner, M., Chollet, J., Nkunya, M.H.H. and Heinrich, M. (1995) Tanzanian medicinal plants used traditionally for the treatment of malaria:In vivo antimalarial andin vitro cytotoxic activities. Phytotherapy Research, 9 (7). pp. 504-508.

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Abstract

Seventeen fractions of extracts obtained from 11 Tanzanian medicinal plants, which had previously been shown to possess a high antimalarial activity in vitro were submitted to the 4-day suppressive test in Plasmodium berghei-infected mice, and were investigated for cytotoxic activity in human carcinoma cell lines in vitro. Several fractions administered orally to the mice (500 mg/kg body weight/day) produced a significant reduction of parasitaemia. The most effective plant fractions investigated were those of the root and stem bark of Maytenus senegalensis (90% and 63% suppression of parasitaemia, respectively) and of the roots of Cissampelos mucronata (59% suppression). Highest cytotoxic activities were found with all fractions of Maytenus senegalensis (IC50 < 1 μg/mL) and with the PE fraction of the roots of Salacia madagascariensis (median IC50 = 1.2 μg/mL for HT 29 and 2.3 μg/mL for KB).

Item Type:Article
Uncontrolled Keywords:Human cell lines; In vitro cytotoxicity; In vivo antimalarial activity; Plant extracts; Plasmodium berghei; Tanzania; Traditional medicine
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Centre for Pharmacognosy and Phytotherapy
ID Code:2717
Journal or Publication Title:Phytotherapy Research
Deposited By:Library Staff
Deposited On:20 Jan 2012 10:09
Last Modified:20 Jan 2012 10:09

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