Biological and pharmacological activities and further constituents of Hyptis verticillata.

Kuhnt, M., Pröbstle, A., Rimpler, H., Bauer, R. and Heinrich, M. (1995) Biological and pharmacological activities and further constituents of Hyptis verticillata. Planta Medica, 61 (3). pp. 227-232. 10.1055/s-2006-958061.

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DOI: 10.1055/s-2006-958061

Abstract

Several extracts of Hyptis verticillata and isolated compounds were evaluated for their anti-inflammatory, antibacterial, antisecretory, and cytotoxic properties. The aerial parts yielded (R)-5-hydroxypyrrolidin-2-one and essential oil with the main components alpha-pinene, beta-pinene, and thymol. Spectroscopic methods (UV, IR, 1H-NMR, 13C-NMR, mass, CD) fully characterized (R)-5-hydroxypyrrolidin-2-one, as it was isolated by a bioassay guided fractionation. The essential oil, (R)-5-hydroxypyrrolidin-2-one, as well as the previously isolated rosmarinic acid and dehydropodophyllotoxine contributed to the antibacterial effects of H. verticillata. Furthermore, rosmarinic acid showed significant capillary stabilizing effects. Sideritoflavone inhibited prostaglandin synthase to a significant extent and had antisecretory effects comparable to those of NPPB. The cytotoxicity of the aqueous extract, as demonstrated using KB and HT 29 cell lines, may be of toxicological relevance in cases of internal application.

Item Type:Article
Uncontrolled Keywords:Hyptis verticillata - Labiatae - (R)-5-hydroxypyrrolidin-2-one - essential oil - antibacterial - anti-inflammatory - antisecretory - cytotoxic - quantification
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Centre for Pharmacognosy and Phytotherapy
ID Code:2719
Journal or Publication Title:Planta Medica
Deposited By:Library Staff
Deposited On:20 Jan 2012 10:22
Last Modified:20 Jan 2012 10:22

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