Inhibition of Intestinal Chloride Secretion by Proanthocyanidins fromGuazuma ulmifolia

Hör, M., Rimpler, H. and Heinrich, M. (1995) Inhibition of Intestinal Chloride Secretion by Proanthocyanidins fromGuazuma ulmifolia. Planta Medica, 61 (03). p. 208. 10.1055/s-2006-958057.

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DOI: 10.1055/s-2006-958057


The antisecretory activity of Guazuma ulmifolia bark was examined in rabbit distal colon mounted in an Ussing chamber. Chloride secretion was stimulated by cholera toxin and prostaglandin E2 (PGE2). Guazuma ulmifolia extract (GUE) completely inhibited cholera toxin-induced secretion if the extract was added to the mucosal bath prior to the toxin. Adding the extract after administration of the toxin had no effect on secretion. GUE did not inhibit PGE2-induced chloride secretion. These results indicate an indirect antisecretory mechanism. SDS-PAGE analysis of cholera toxin treated with GUE confirmed this presumption. GUE specifically interacted with the A subunit of the toxin. Preliminary phytochemical examinations showed that the most active fraction contains procyanidins with a degree of polymerisation higher than 8.

Item Type:Article
Uncontrolled Keywords:chloride secretion; cholera toxin; diarrhoea; Guazuma ulmifolia; proanthocyanidins; prostaglandin E2; Sterculiaceae; tannins; Ussing chamber
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Centre for Pharmacognosy and Phytotherapy
ID Code:2720
Journal or Publication Title:Planta Medica
Deposited By:Library Staff
Deposited On:20 Jan 2012 10:25
Last Modified:20 Jan 2012 10:25

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