Stabilisation of human telomeric quadruplex DNA and inhibition of telomerase by a platinum-phenanthroline complex.

Reed, J.E., Neidle, S. and Vilar, R. (2007) Stabilisation of human telomeric quadruplex DNA and inhibition of telomerase by a platinum-phenanthroline complex. Chemical Communications (42). pp. 4366-4368. 10.1039/B709898G .

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DOI: 10.1039/B709898G

Abstract

Two new mono-substituted phenanthroline ligands and their platinum(II) square planar complexes have been prepared; one of the complexes has been shown to induce a high degree of quadruplex DNA stabilisation and to inhibit telomerase.

Item Type:Article
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry
ID Code:2740
Journal or Publication Title:Chemical Communications
Deposited By:Library Staff
Deposited On:20 Jan 2012 15:00
Last Modified:20 Jan 2012 15:00

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