Highly prevalent putative quadruplex sequence motifs in human DNA

Todd, A. K., Johnston, M. and Neidle, S. (2005) Highly prevalent putative quadruplex sequence motifs in human DNA. Nucleic Acids Research, 33 (9). pp. 2901-2907. 10.1093/nar/gki553.

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DOI: 10.1093/nar/gki553

Abstract

We report here the results of a systematic search for the existence and prevalence of potential intramolecular G-quadruplex forming sequences in the human genome. We have also examined the tendency for particular sequences of 'loop' regions to occur in particular positions with respect to the G-tracts in a quadruplex. Using arithmetic ratio and probability techniques we have discovered frequent and systematic occurrence of certain sequence types, the most prominent being a potential quadruplex containing CCTGT in the first 'loop' position. Being able to highlight types of potential quadruplex sequences in G-rich regions is an important step in searching for biologically relevant sequences and finding their function.

Item Type:Article
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry
ID Code:2743
Journal or Publication Title:Nucleic Acids Research
Deposited By:Library Staff
Deposited On:20 Jan 2012 15:31
Last Modified:20 Jan 2012 15:31

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