Fast gelation of self-assembling peptide nanofibres triggered by electromagnetic radiation heating

Mazza, M., Gaisford, S., McCarthy, D., Schatzlein, A.G. and Uchegbu, I.F. (2011) Fast gelation of self-assembling peptide nanofibres triggered by electromagnetic radiation heating. In: Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011. NSTI-Nanotech, pp. 650-653. ISBN 978-143987142-3.

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Abstract

Peptides and peptide amphiphiles are able to form nanoscale ordered hydrogels. We report a method for the preparation of such nanofibre based gels. These gels are prepared by a rapid microwave heating and cooling cycle. An amphiphilic derivative of the hydrophilic hexapeptide dalargin, in which a C 16 acyl chain is attached via an ester linkage to the tyrosine residue (palmitoyl dalargin - pDal) was used to construct the nanofibre gels. The thermal properties of pDal were analyzed using differential scanning calorimetry (DSC) and Hot Stage Microscopy (HSM). When a dilute dispersion of pDal freeze dried solid (1mg mL -1) is microwave heated in short bursts, at the acyl chain melting temperature (88°C, 10) nanofibres with a diameter of 8-20 nm are formed; heating a more concentrated dispersion (10 mg mL -1) results in the formation of a nanofibre gel. Our findings show that microwave heating of peptide amphiphiles, bearing acyl chains is a reproducible method of producing peptide nanofibre gels.

Item Type:Book Section
Additional Information:Nanotechnology 2011: Advanced Materials, CNTs, Particles, Films and Composites - 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011; Boston, MA; 13-16 June 2011; Code 87282
Uncontrolled Keywords:Gel; Microwave; Nanofibres; Peptide; Self-assembly
Departments, units and centres:Department of Pharmaceutics > Department of Pharmaceutics
ID Code:2796
Deposited By:Library Staff
Deposited On:10 Feb 2012 11:14
Last Modified:10 Feb 2012 11:14

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