Vibrating-mesh nebulization of liposomes generated using an ethanol-based proliposome technology

Elhissi, A.M.A., Gill, H., Ahmed, W. and Taylor, K.M.G. (2011) Vibrating-mesh nebulization of liposomes generated using an ethanol-based proliposome technology. Journal of Liposome Research, 21 (2). pp. 173-180. 10.3109/08982104.2010.505574.

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DOI: 10.3109/08982104.2010.505574

Abstract

This is the first study that evaluates the influence of the compartmental design of the micropump Aeroneb Go nebulizer and the viscosity of a proliposome hydration medium on vibrating-mesh aerosolization of liposomes. Ethanol-based proliposomes comprising soya phosphatidylcholine and cholesterol (1:1 mole ratio) were hydrated by using isotonic NaCl (0.9%) or sucrose (9.25%) solutions to generate liposomes that entrapped approximately 61% of the hydrophilic drug, salbutamol sulphate. Liposomes were aerosolized by the nebulizer to a two-stage impinger. For both formulations, the aerosol mass output was higher than the phospholipid output, indicating some accumulation of large liposomes or liposome aggregate within the nebulizer. Using NaCl (0.9%) solution as the dispersion medium, aerosol droplet size was much smaller and aerosol mass and phospholipid outputs were higher. This was attributed to the lower viscosity of the NaCl solution, resulting in a reduced retention of the aerosols in the "trap" of the nebulizer. For the entrapped salbutamol sulphate, although the "fine particle fraction" was relatively high (57.44%), size reduction of the liposomes during nebulization caused marked losses of the drug originally entrapped. Overall, liposomes generated from proliposomes when using this nebulizer showed high nebulization output and small droplet size. However, further work is required to reduce the losses of the originally entrapped drug from liposomes

Item Type:Article
Uncontrolled Keywords:Aerosol; liposome; nebulizer; proliposome; pulmonary delivery; salbutamol sulphate
Departments, units and centres:Department of Pharmaceutics > Department of Pharmaceutics
ID Code:2801
Journal or Publication Title:Journal of Liposome Research
Deposited By:Library Staff
Deposited On:10 Feb 2012 11:46
Last Modified:10 Feb 2012 11:46

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