Making carbon nanotubes biocompatible and biodegradable

Bianco, A., Kostarelos, K. and Prato, M. (2011) Making carbon nanotubes biocompatible and biodegradable. Chemical Communications, 47 (37). pp. 10182-10188. 10.1039/c1cc13011k.

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DOI: 10.1039/c1cc13011k

Abstract

Carbon nanotubes are promising nanomaterials with great potential in the field of nanomedicine for both therapeutic and diagnostic applications. Different approaches have been developed to render this material biocompatible and to modulate any ensuing toxic effects. In the context of medical use, although chemically functionalised carbon nanotubes display reduced toxicity, they are still considered with scepticism due to their perceived non-biodegradability. Recently, it has been demonstrated that functionalised carbon nanotubes can be degraded by oxidative enzymes. This finding is offering a new perspective for the development of carbon nanotubes in medicine. This article highlights recent advances that can act as paradigm-shifts towards the design of biocompatible and biodegradable functionalised carbon nanotubes and allow their translation into the clinic.

Item Type:Article
Departments, units and centres:Department of Pharmaceutics > Department of Pharmaceutics
ID Code:2839
Journal or Publication Title:Chemical Communications
Deposited By:Library Staff
Deposited On:24 Feb 2012 10:05
Last Modified:24 Feb 2012 10:05

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