Length-Dependent Retention of Carbon Nanotubes in the Pleural Space of Mice Initiates Sustained Inflammation and Progressive Fibrosis on the Parietal Pleura

Murphy, F.A., Poland, C.A., Duffin, R., Al-Jamal, K.T., Ali-Boucetta, H., Nunes, A., Byrne, F., Prina-Mello, A., Volkov, Y., Liu, S., Mather, S.J., Bianco, A., Prato, M., MacNee, W., Wallace, W.A., Kostarelos, K. and Donaldson, K. (2011) Length-Dependent Retention of Carbon Nanotubes in the Pleural Space of Mice Initiates Sustained Inflammation and Progressive Fibrosis on the Parietal Pleura. American Journal of Pathology, 178 (6). pp. 2587-2600. 10.1016/j.ajpath.2011.02.040.

Full text not available from this repository.

DOI: 10.1016/j.ajpath.2011.02.040

Abstract

The fibrous shape of carbon nanotubes (CNTs) raises concern that they may pose an asbestos-like inhalation hazard, leading to the development of diseases, especially mesothelioma. Direct instillation of long and short CNTs into the pleural cavity, the site of mesothelioma development, produced asbestos-like length-dependent responses. The response to long CNTs and long asbestos was characterized by acute inflammation, leading to progressive fibrosis on the parietal pleura, where stomata of strictly defined size limit the egress of long, but not short, fibers. This was confirmed by demonstrating clearance of short, but not long, CNT and nickel nanowires and by visualizing the migration of short CNTs from the pleural space by single-photon emission computed tomographic imaging. Our data confirm the hypothesis that, although a proportion of all deposited particles passes through the pleura, the pathogenicity of long CNTs and other fibers arises as a result of length-dependent retention at the stomata on the parietal pleura.

Item Type:Article
Departments, units and centres:Department of Pharmaceutics > Department of Pharmaceutics
ID Code:2844
Journal or Publication Title:American Journal of Pathology
Deposited By:Library Staff
Deposited On:24 Feb 2012 10:39
Last Modified:04 May 2012 11:51

Repository Staff Only: Item control page

School of Pharmacy Staff Only: Edit a copy to replace this item