Blood Circulation and Tissue Biodistribution of Lipid−Quantum Dot (L-QD) Hybrid Vesicles Intravenously Administered in Mice

Al-Jamal, W.T., Al-Jamal, K.T., Cakebread, A., Halket, J.M. and Kostarelos, K. (2009) Blood Circulation and Tissue Biodistribution of Lipid−Quantum Dot (L-QD) Hybrid Vesicles Intravenously Administered in Mice. Bioconjugate Chemistry, 20 (9). pp. 1696-1702. 10.1021/bc900047n.

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DOI: 10.1021/bc900047n

Abstract

The present work describes the pharmacokinetics of recently developed liposome-quantum dot (L-QD) hybrid vesicles in nude mice following systemic administration. Hydrophobic QD were incorporated into different bilayer compositions, and the serum stability of such hybrid vesicles was evaluated using turbidity and carboxyfluorescein release measurements. L-QD hybrid blood profile and organ biodistribution were also determined by elemental (cadmium) analysis. Following intravenous administration, different tissue biodistribution profiles and tissue affinities were observed depending on the L-QD lipid bilayer characteristics. Immediate blood clearance was observed with cationic (DOTAP/DOPE/Chol) hybrid with rapid lung accumulation, while incorporation of PEG at the surface of zwitterionic vesicles dramatically prolonged their blood circulation half-life after systemic administration. Overall, the L-QD hybrid vesicle system is considered a viable platform that allows QD delivery to different tissues through facile modulation of the hybrid vesicle characteristics. In addition, L-QD offers many opportunities for the development of combinatory therapeutic and imaging (theranostic) modalities by incorporating both drug molecules and QD within the different compartments of a single vesicle.

Item Type:Article
Departments, units and centres:Department of Pharmaceutics > Department of Pharmaceutics
ID Code:2849
Journal or Publication Title:Bioconjugate Chemistry
Deposited By:Library Staff
Deposited On:24 Feb 2012 14:10
Last Modified:04 May 2012 10:53

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