One-Pot Synthesis of Fused-Tetracyclic Scaffolds Employing a Lewis Acid Promoted Domino Reaction of Naphthoquinones

Bendiabdellah, Y., Villanueva-Margalef, I., Misale, A., Nahar, K., Haque, M.R., Thurston, D.E. and Zinzalla, G. (2011) One-Pot Synthesis of Fused-Tetracyclic Scaffolds Employing a Lewis Acid Promoted Domino Reaction of Naphthoquinones. Synthesis, 2011 (14). pp. 2321-2333. 10.1055/s-0030-1260073.

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DOI: 10.1055/s-0030-1260073

Abstract

The facile synthesis of tetracyclic molecular frameworks employing a Lewis acid promoted domino reaction of naphthoquinones with hydroxy- and amino-functionalized cross-conjugated trienes is reported. The reaction cascade involves a heterocyclization via hemiacetal or imine formation, and an intramolecular Diels-Alder cycloaddition

Item Type:Article
Uncontrolled Keywords:intramolecular Diels-Alder cycloaddition; Lewis acid promoted domino reaction; naphthoquinone; tetracyclic scaffolds
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry
ID Code:2883
Journal or Publication Title:Synthesis
Deposited By:Library Staff
Deposited On:01 Mar 2012 10:42
Last Modified:01 Mar 2012 10:42

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