G-Quadruplexes and Metal Ions

Campbell, N.H. and Neidle, S. (2011) G-Quadruplexes and Metal Ions. Metal Ions in Life Sciences, 10 . pp. 119-134. 10.1007/978-94-007-2172-2_4.

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DOI: 10.1007/978-94-007-2172-2_4


Metal ions stabilize quadruplex nucleic acids by coordinating the O6 guanine atoms from G-quartets. These quartets form the basic motif of quadruplex structures. This article systematically surveys the available crystallographic data on native quadruplexes, their ligand complexes and (in one instance) a protein complex. Three categories of quadruplex are examined, tetramolecular, bimolecular, and intramolecular: all are formed by telomeric nucleic acid sequences from human or ciliate organisms.

Item Type:Article
Additional Information:Interplay between Metal Ions and Nucleic Acids Astrid Sigel, Helmut Sigel and Roland K. O. Sigel
Uncontrolled Keywords:crystal structures – ion channel – metal ion coordination – Protein Data Bank – quadruplex
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry
ID Code:2887
Journal or Publication Title:Metal Ions in Life Sciences
Deposited By:Library Staff
Deposited On:01 Mar 2012 11:54
Last Modified:01 Mar 2012 11:54


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