Campbell, N.H. and Neidle, S. (2011) G-Quadruplexes and Metal Ions. Metal Ions in Life Sciences, 10 . pp. 119-134. 10.1007/978-94-007-2172-2_4.
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Metal ions stabilize quadruplex nucleic acids by coordinating the O6 guanine atoms from G-quartets. These quartets form the basic motif of quadruplex structures. This article systematically surveys the available crystallographic data on native quadruplexes, their ligand complexes and (in one instance) a protein complex. Three categories of quadruplex are examined, tetramolecular, bimolecular, and intramolecular: all are formed by telomeric nucleic acid sequences from human or ciliate organisms.
|Additional Information:||Interplay between Metal Ions and Nucleic Acids Astrid Sigel, Helmut Sigel and Roland K. O. Sigel|
|Uncontrolled Keywords:||crystal structures – ion channel – metal ion coordination – Protein Data Bank – quadruplex|
|Departments, units and centres:||Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry|
|Journal or Publication Title:||Metal Ions in Life Sciences|
|Deposited By:||Library Staff|
|Deposited On:||01 Mar 2012 11:54|
|Last Modified:||01 Mar 2012 11:54|
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