Isolation and characterization of a new anticancer diterpenoid from Jatropha gossypifolia

Falodun, A., Sheng-Xiang, Q., Parkinson, G.N. and Gibbons, S. (2012) Isolation and characterization of a new anticancer diterpenoid from Jatropha gossypifolia. Pharmaceutical Chemistry Journal, 45 (10). pp. 636-639. 10.1007/s11094-012-0693-4.

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DOI: 10.1007/s11094-012-0693-4

Abstract

Jatropha gossypifolia root bark is used in ethnomedicine for the treatment of various diseases and infections. We have studied the phytochemistry and evaluated the anticancer activity of J. gossypifolia root extract. Phytochemical investigation of the root of J. gossypifolia resulted in the isolation and characterization of one new diterpenoid along with four well-known compounds. The new compound was established by 1D and 2D NMR spectra and x-ray analysis, while spectral (1H, 13C NMR, and ESI-MS) characteristics of the known compounds were compared with reported data. The new compound showed potent proliferation inhibitory activity against A-549 human cancer cell line.

Item Type:Article
Uncontrolled Keywords:Jatropha gossypifolia – root extract – anticancer activity – lathyrane diterpenes – cytotoxicity
ID Code:2888
Journal or Publication Title:Pharmaceutical Chemistry Journal
Deposited By:Library Staff
Deposited On:01 Mar 2012 14:08
Last Modified:23 Mar 2012 17:22

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