Parallel Synthesis of a Novel C2-Aryl Pyrrolo[2,1-c][1,4]benzodiazepine (PBD) Library

Antonow, D., Cooper, N., Howard, P.W. and Thurston, D.E. (2007) Parallel Synthesis of a Novel C2-Aryl Pyrrolo[2,1-c][1,4]benzodiazepine (PBD) Library. Journal of Combinatorial Chemistry, 9 (3). pp. 437-445. 10.1021/cc0601332.

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DOI: 10.1021/cc0601332

Abstract

A 66-member C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) library has been successfully synthesized in parallel via Suzuki coupling using PS-PPh3Pd (catalyst) and PS-DEAM (scavenger) under microwave radiation. Library members were obtained in sufficient yield (up to 91%) and purity (85-98% crude) for biological evaluation.

Item Type:Article
Uncontrolled Keywords:solid-phase synthesis; cross-linking agent; spectrum antitumor-activity; sjg-136 nsc-694501; in-vitro; dna; potent; cytotoxicity
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry
ID Code:2899
Journal or Publication Title:Journal of Combinatorial Chemistry
Deposited By:Library Staff
Deposited On:02 Mar 2012 15:55
Last Modified:02 Mar 2012 15:55

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