A Facile Synthesis of C2-Substituted Pyrrolo[2,3-f]quinolines with Cytotoxic Activity

Tsotinis, A., Vlachou, M., Zouroudis, S., Jeney, A., Timar, F., Thurston, D.E. and Roussakis, C. (2005) A Facile Synthesis of C2-Substituted Pyrrolo[2,3-f]quinolines with Cytotoxic Activity. Letters in Drug Design and Discovery, 2 (3). pp. 189-192. 10.2174/1570180053765075.

Full text not available from this repository.

DOI: 10.2174/1570180053765075

Abstract

An expeditious four-step synthesis of the 1H-pyrrolo[2,3-f]quinoline-2- carboxamides (5a-h) is described. Readily available 6-quinolinecarboxaldehyde is converted to the parent acid (6) by nucleophilic attack of the azido-ester (9) and intramolecular cyclization of (10) followed by hydrolysis of the methyl ester (11). The cytotoxicity of the target molecules (5a-h) was evaluated in four tumour cell lines in vitro. One compound (5d) showed sufficient activity (IC50 = 10.2 μM) in the human non-small cell lung cell line NSCLC-N16-L16 to be worthy of further study.

Item Type:Article
Uncontrolled Keywords:Cytotoxicity; Pyrrolo[2,3-f]quinolines; Synthesis
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry
ID Code:2908
Journal or Publication Title:Letters in Drug Design and Discovery
Deposited By:Library Staff
Deposited On:08 Mar 2012 10:48
Last Modified:08 Mar 2012 10:48

Repository Staff Only: Item control page

School of Pharmacy Staff Only: Edit a copy to replace this item