Vlachou, M., Tsotinis, A., Kelland, L.R. and Thurston, D.E. (2002) An expeditious synthesis of cytotoxic pyrroloisoquinoline derivatives. Structure-activity comparative studies with isomeric pyrroloquinolines. European Journal of Pharmaceutical Sciences, 17 (3). pp. 139-143. 10.1016/S0928-0987(02)00163-X.
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DOI: 10.1016/S0928-0987(02)00163-X
Abstract
A number of pyrroloisoquinolines have been prepared by reaction of 5-nitroisoquinoline with vinylmagnesium bromide followed by N-alkylation with the appropriate 2-chloro-N,N-dialkylethylamine. Their cytotoxicity was evaluated in a number of ovarian cell lines and compared to their analogous isomeric pyrroloquinolines. Two of the new compounds, 7c and 7d, are selective toward the A2780 cisplatin-resistant line.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Cytotoxic activity; Pyrroloisoquinolines; Pyrroloquinolines; Synthesis |
| Departments, units and centres: | Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry |
| ID Code: | 2919 |
| Journal or Publication Title: | European Journal of Pharmaceutical Sciences |
| Deposited By: | Library Staff |
| Deposited On: | 08 Mar 2012 16:39 |
| Last Modified: | 08 Mar 2012 16:39 |
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