An expeditious synthesis of cytotoxic pyrroloisoquinoline derivatives. Structure-activity comparative studies with isomeric pyrroloquinolines.

Vlachou, M., Tsotinis, A., Kelland, L.R. and Thurston, D.E. (2002) An expeditious synthesis of cytotoxic pyrroloisoquinoline derivatives. Structure-activity comparative studies with isomeric pyrroloquinolines. European Journal of Pharmaceutical Sciences, 17 (3). pp. 139-143. 10.1016/S0928-0987(02)00163-X.

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DOI: 10.1016/S0928-0987(02)00163-X

Abstract

A number of pyrroloisoquinolines have been prepared by reaction of 5-nitroisoquinoline with vinylmagnesium bromide followed by N-alkylation with the appropriate 2-chloro-N,N-dialkylethylamine. Their cytotoxicity was evaluated in a number of ovarian cell lines and compared to their analogous isomeric pyrroloquinolines. Two of the new compounds, 7c and 7d, are selective toward the A2780 cisplatin-resistant line.

Item Type:Article
Uncontrolled Keywords:Cytotoxic activity; Pyrroloisoquinolines; Pyrroloquinolines; Synthesis
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry
ID Code:2919
Journal or Publication Title:European Journal of Pharmaceutical Sciences
Deposited By:Library Staff
Deposited On:08 Mar 2012 16:39
Last Modified:08 Mar 2012 16:39

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