Synthesis of novel C2-aryl pyrrolobenzodiazepines (PBDs) as potential antitumour agents

Cooper, N., Hagan, D.R., Tiberghien, A., Ademefun, T., Matthews, C.S., Howard, P.W. and Thurston, D.E. (2002) Synthesis of novel C2-aryl pyrrolobenzodiazepines (PBDs) as potential antitumour agents. Chemical Communications (16). pp. 1764-1765. 10.1039/B205136B.

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DOI: 10.1039/B205136B

Abstract

Three novel C2-aryl substituted pyrrolobenzodiazepines (PBDs) have been synthesised and evaluated in a number of cell lines revealing selective cytotoxicity at the sub-nanomolar level towards melanoma and ovarian cancer cell lines.

Item Type:Article
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry
ID Code:2920
Journal or Publication Title:Chemical Communications
Deposited By:Library Staff
Deposited On:08 Mar 2012 16:51
Last Modified:08 Mar 2012 16:51

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