Synthesis and biological evaluation of an N10-Psec substituted pyrrolo[2,1-c][1,4]benzodiazepine prodrug.

Berry, J.M., Howard, P.W., Kelland, L.R. and Thurston, D.E. (2002) Synthesis and biological evaluation of an N10-Psec substituted pyrrolo[2,1-c][1,4]benzodiazepine prodrug. Bioorganic and Medicinal Chemistry Letters, 12 (10). pp. 1413-1416. 10.1016/S0960-894X(02)00150-6.

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DOI: 10.1016/S0960-894X(02)00150-6

Abstract

The first example of an N10-protected (e.g., Psec, 15) pyrrolo[2,1-c][1,4]benzodiazepine (PBD) analogue that retains significant cytotoxicity in a number of tumour cell lines is reported. This prototype could lead to a new generation of clinically useful N10-protected PBD prodrugs.

Item Type:Article
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry
ID Code:2921
Journal or Publication Title:Bioorganic and Medicinal Chemistry Letters
Deposited By:Library Staff
Deposited On:08 Mar 2012 17:13
Last Modified:08 Mar 2012 17:13

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