Design and synthesis of novel pyrrolobenzodiazepine (PBD) prodrugs for ADEPT and GDEPT.

Sagnou, M.J., Howard, P.W., Gregson, S.J., Eno-Amooquaye, E., Burke, P.J. and Thurston, D.E. (2000) Design and synthesis of novel pyrrolobenzodiazepine (PBD) prodrugs for ADEPT and GDEPT. Bioorganic and Medicinal Chemistry Letters, 10 (18). pp. 2083-2086. 10.1016/S0960-894X(00)00404-2.

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DOI: 10.1016/S0960-894X(00)00404-2

Abstract

Three N10-(4-nitrobenzyl)carbamate-protected PBD prodrugs (9a, 9b and 15) have been synthesized and evaluated for potential use in nitroreductase-based ADEPT and GDEPT therapies. An approximately 100-fold activation was observed for the DC-81 prodrug 9a.

Item Type:Article
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry
ID Code:2924
Journal or Publication Title:Bioorganic and Medicinal Chemistry Letters
Deposited By:Library Staff
Deposited On:09 Mar 2012 09:49
Last Modified:09 Mar 2012 09:49

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