Sagnou, M.J., Howard, P.W., Gregson, S.J., Eno-Amooquaye, E., Burke, P.J. and Thurston, D.E. (2000) Design and synthesis of novel pyrrolobenzodiazepine (PBD) prodrugs for ADEPT and GDEPT. Bioorganic and Medicinal Chemistry Letters, 10 (18). pp. 2083-2086. 10.1016/S0960-894X(00)00404-2.
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Three N10-(4-nitrobenzyl)carbamate-protected PBD prodrugs (9a, 9b and 15) have been synthesized and evaluated for potential use in nitroreductase-based ADEPT and GDEPT therapies. An approximately 100-fold activation was observed for the DC-81 prodrug 9a.
|Departments, units and centres:||Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry|
|Journal or Publication Title:||Bioorganic and Medicinal Chemistry Letters|
|Deposited By:||Library Staff|
|Deposited On:||09 Mar 2012 09:49|
|Last Modified:||09 Mar 2012 09:49|
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