Sagnou, M.J., Howard, P.W., Gregson, S.J., Eno-Amooquaye, E., Burke, P.J. and Thurston, D.E. (2000) Design and synthesis of novel pyrrolobenzodiazepine (PBD) prodrugs for ADEPT and GDEPT. Bioorganic and Medicinal Chemistry Letters, 10 (18). pp. 2083-2086. 10.1016/S0960-894X(00)00404-2.
Full text not available from this repository.
DOI: 10.1016/S0960-894X(00)00404-2
Abstract
Three N10-(4-nitrobenzyl)carbamate-protected PBD prodrugs (9a, 9b and 15) have been synthesized and evaluated for potential use in nitroreductase-based ADEPT and GDEPT therapies. An approximately 100-fold activation was observed for the DC-81 prodrug 9a.
| Item Type: | Article |
|---|---|
| Departments, units and centres: | Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry |
| ID Code: | 2924 |
| Journal or Publication Title: | Bioorganic and Medicinal Chemistry Letters |
| Deposited By: | Library Staff |
| Deposited On: | 09 Mar 2012 09:49 |
| Last Modified: | 09 Mar 2012 09:49 |
Statistics
Item downloaded times since 09 Mar 2012 09:49.
Repository Staff Only: Item control page
School of Pharmacy Staff Only: Edit a copy to replace this item